Media Exposure, Juror Decision-Making, and the Availability Heuristic

Although much of the research regarding media exposure has centered on the harmful effects of pretrial publicity in criminal cases, it has been argued that civil cases may be more vulnerable to its effects compared to criminal cases (Bornstein, Whisenhunt, Nemeth, & Dunaway, 2002). In large part this appears to be due to the potential influence of media depiction of high-profile lawsuits and atypical verdict awards on judgments of liability and damages (Robbennolt & Studebaker, 2003). In our study we examined the effect of exposure to a news article (relating a verdict award in a product liability case) on juror decision-making in a conceptually similar case. We varied the amount of damages awarded by the jury in the news article as well as the amount of time between reading the article and the case summary. Our goal wasto investigate whether and to what extent jurors use available information when awarding damages. In addition, we were interested in the influence of media exposure on perceptions of the plaintiff and defendan

The role of the CCN family of proteins in blood cancers

Haematopoiesis is the term used to describe the production of blood cells. This is a tightly regulated hierarchical system in which mature circulating blood cells develop from a small population of haematopoietic stem (HSC) and progenitor cells within the microenvironment of the bone marrow. Molecular and genetic abnormalities arising in these stem cells lead to a block in the normal programme of proliferation and differentiation and result in the development of the blood cancers known as the leukaemias and lymphomas. Recently the regulatory role of the bone marrow microenvironment or niche has also become increasingly recognised. The interface between the bone and bone marrow (endosteum) and the region surrounding the blood vessels (perivascular) provide distinct niches harbouring quiescent HSC or proliferative HSC respectively. Current chemotherapeutic regimes can often successfully target the proliferative HSC but disease relapse occurs due to residual quiescent HSC. Understanding these developmental and regulatory processes and the associated cell communication mechanisms are thus crucial to the development of new treatment strategies. The CCN family of proteins have been recognised to play a key role in all aspects of haematopoiesis

Losing Weight: A KECK Spectroscopic Survey of the Massive Cluster of Galaxies RX J1347-1145

We present a sample of 47 spectroscopically confirmed members of RX J1347-1145, the most luminous X-ray cluster of galaxies discovered to date. With two exceptions, all the galaxies in this sample have red B-R colors and red spectral indices, with spectra similar to old local ellipticals. Using all 47 cluster members, we derive a mean redshift of 0.4509\pm 0.003, and a velocity dispersion of 910\pm130 km/sec, which corresponds to a virial mass of 4.4 x 10^{14} h^{-1} Solar masses with an harmonic radius of 380 h^{-1} kpc. The derived total dynamical mass is marginally consistent with that deduced from the cluster's X-ray emission based on the analysis of ROSAT/ASCA images (Schindler et al. 1997), but not consistent with the more recent X-ray analyses of Allen (2000), Ettori, Allen & Fabian (2001) and Allen, Schmidt & Fabian (2002). Furthermore, the dynamical mass is significantly smaller than that derived from weak lensing (Fischer & Tyson 1997) and from strong lensing (Sahu et al. 1998). We propose that these various discrepant mass estimates may be understood if RX J1347-1145 is the product of two clusters caught in the act of merging in a direction perpendicular to the line of sight, although there is no evidence from the galaxy redshift distribution supporting this hypothesis. Even with this hypothesis, a significant part of the extremely high X-ray luminosity must still arise from non-virialized, presumably shocked, gas. Finally, we report the serendipitous discovery of a lensed background galaxy at z=4.083 which will put strong constraints on the lensing mass determination once its counter-image is securely identified.Comment: Minor changes to conform to version accepted by Ap

'Vices and virtues' : re-edited from British Library MS Stowe 34.

'Vices and Virtues' is an early Middle English homiletic dialogue between Reason, the Soul and the Body, originally edited by Ferdinand Holthausen in 1888, with Notes and Glossary published in 1921. This edition contains an Introduction, the re-edited Text, Notes on the text, a full etymological Glossary, and a Bibliography of works cited or referred to in the preparation of the edition. The Introduction is concerned principally with an analysis of the language of 'Vices and Virtues', and suggests a provenance of London, or the areas of Essex or Middlesex just to the north of London, and a date of c. 1200. It also contains a general introduction to the work and the background against which it is presumed to have been written, a description of the MS and notes on the characteristics of the scribes who worked on it, and brief surveys of the syntax, style and structure of the work, together with a statement of editorial principles. The Notes to the text are concerned principally with the language, both grammar and vocabulary, and with sources and parallels in Patristic writings and other medieval texts

Determination of Biotransformation and Biodegradation Rate Constants for Naphthalene, Lindane and Phenol

Biotransformation and biodegradation rate constants were determined for naphthalene, lindane, and phenol in water samples from three different sources. Rate constants produced from monitoring disappearance of the parent chemical (biotransformation) were compared to those obtained from mineralization of the chemical (ultimate biodegradation) by ¹⁴CO₂ evolution as well as acidification of the residual ¹⁴C-labeled compound (primary biodegradation). Rate constants were statistically different for the three chemicals. The water source affected the rate constants. When biomass measurements of the waters were considered and second-order rate constants were derived, there was no statistical evidence that this parameter gave a reliable rate constant statistic that could be useful in predicting the fate of any of naphthalene, lindane, and phenol in these waters

A third-person perspective on co-speech action gestures in Parkinson's disease

A combination of impaired motor and cognitive function in Parkinson’s disease (PD) can impact on language and communication, with patients exhibiting a particular difficulty processing action verbs. Co-speech gestures embody a link between action and language and contribute significantly to communication in healthy people. Here, we investigated how co-speech gestures depicting actions are affected in PD, in particular with respect to the visual perspective—or the viewpoint – they depict. Gestures are closely related to mental imagery and motor simulations, but people with PD may be impaired in the way they simulate actions from a first-person perspective and may compensate for this by relying more on third-person visual features. We analysed the action-depicting gestures produced by mild-moderate PD patients and age-matched controls on an action description task and examined the relationship between gesture-viewpoint, action-naming, and performance on an action observation task (weight judgement). Healthy controls produced the majority of their action-gestures from a first person perspective, whereas PD patients produced a greater proportion of gestures produced from a third person perspective. We propose that this reflects a compensatory reliance on third-person visual features in the simulation of actions in PD. Performance was also impaired in action-naming and weight judgement, although this was unrelated to gesture viewpoint. Our findings provide a more comprehensive understanding of how action-language impairments in PD impact on action communication, on the cognitive underpinnings of this impairment, as well as elucidating the role of action simulation in gesture production

The Role of Multiple Sclerosis as a Risk Factor for the Development of Osteoporosis

Background: Osteoporosis is the most common bone disease in the United States, and it is particularly common among women with multiple sclerosis (MS). However, despite this association, the temporal relationship between these two conditions has not been previously studied. Data from the Women’s Health Initiative provides a unique opportunity to examine the risk of developing osteoporosis over time in individuals diagnosed with MS. Objective: The purpose of this study is to refine the relationship between MS and osteoporosis, clarifying the impact of environmental and pharmacologic factors on each condition, as well as addressing treatment and preventative efforts for a patient population at a greater potential risk for osteoporosis. Methods: The study sample, derived from the Women’s Health Initiative, included 449 women who reported an MS diagnosis at baseline and 161,359 women without MS who comprised a control group. Baseline measures of self-reported osteoporosis, age, smoking status, steroid and anti-inflammatory use, and supplementary as well as dietary calcium and vitamin D were compared. MS patients reporting osteoporosis at baseline were removed, resulting in 355 women with MS to monitor for time to incident osteoporosis. Survival analyses were performed on follow-up data gathered annually between 1993 and 2005 to factor out significant associations of additional factors. Proportions of participants on osteoporosis-related medications as well as latency to use were compared between the multiple sclerosis and control cohorts. Results: At baseline, women with MS are nearly three times as likely to report osteoporosis (p Conclusions: A higher prevalence of osteoporosis at baseline suggests MS may significantly increase the risk of osteoporosis in premenopausal women. In contrast, environmental and pharmacologic variables appear to have a more significant role in the post-menopausal population. While osteoporosis was treated similarly between both groups, the point for intervention or prevention of osteoporosis in MS patients may be earlier in the disease course